Fabry disease refers to a group of anadrol reviews recessive lysosomal storage disease, developing as a result of lack of lysosomal alpha-galactosidase A. Agalsidaza alfa catalyses the hydrolysis of glycosphingolipids , splitting off terminal galactose residues from the molecule. Enzyme deficiency leads to disruption of glycosphingolipid metabolism that accumulate in the walls of blood vessels and tissues of many organs, causing a violation of their structure and function. agalsidazoy alpha Substitution therapy decreases the accumulation of in many cells, including endothelial and parenchymal cells.
Alpha Agalsidaza performed on human cell lines. Glycosylation profile similar to the profile of the natural enzyme alpha agalsidaze allows to specifically bind to mannose-6-phosphate receptors on the surface of target cells.
The pharmacokinetic parameters do not differ significantly in men and women. The half-life of alpha agalsidazy blood of men after intravenous, single injection at a dose of anadrol reviews minutes in females 89 ± 28 minutes, volume of distribution – about 17% of the weight of the patients of both sexes, body.Given the similarity of pharmacokinetic properties agalsidazy alpha in patients of both sexes, the distribution in major tissues and organs is also comparable in men and women. In children (aged 7-18 years) Replagal administered at 0.2 mg / kg, output from the circulation faster than adult patients. The average value of clearance Replagala in children aged 7-11 years, adolescents aged 12-18 years and adults was 4.2 ml / min / kg, 3.1 ml / min / kg and 2.3 ml / min / kg, respectively. After 6 months of application Replagala pharmacokinetic parameters were changed – obviously increased ground clearance. These changes are associated with the production of antibodies to the alpha agalsidaze determined in low titer. Clinical significance for safety and efficacy Replagala it did not matter.
The half-life of the drug from the tissues of more than 24 hours, and about 10% of the administered dose is absorbed by the liver.
Agalsidaza alpha metabolized anadrol reviews by peptide hydrolysis, therefore, it is unlikely that the drug will interact with other drugs.
Renal elimination of a minor, hence, impaired renal function does not It affects the pharmacokinetic parameters of the drug.
Impaired liver function has no significant effect on the pharmacokinetics of agalsidazy alpha, taking into account the peculiarities of its metabolism (peptide hydrolysis). steroids.com geneza pharma deca durabolin for sale