Pregnancy and lactation Fertility
There are no data on the effect of the drug anadrol dosage on the reproductive function of women. Men taking the drug does not affect the composition of the sperm morphology and motility.
Pregnancyzidovudine crosses the placenta. The drug can be used before 14 weeks of pregnancy only if the potential benefit to the mother outweighs risk to the fetus. HIV transmission from mother to prevention fetus Use of the drug anadrol dosage after 14 weeks of pregnancy, followed by his appointment in newborns results in a reduction in the frequency of vertical transmission HIV. Long-term effects in children who received it during the prenatal or neonatal period are unknown. We can not completely exclude the possibility of carcinogenic influence. Pregnant women should be informed about it. Pregnant women, suggesting the use during pregnancy to prevent vertical transmission of HIV should be informed about the risk of fetal infection despite ongoing therapy.Lactation Since zidovudine and HIV penetrate into breast milk, in while taking , women should not breast-feed.
Dosing and Administration
The drug anadrol dosage is intended for oral use. Adults and adolescents weighing at least 30 kg the recommended dose is 500 or 600 mg per day, divided into two stages, as part of combination therapy. The dose of 1000 mg per day, divided into several times, were used in clinical trials. Efficacy doses in the range of less than 1000 mg / day for the treatment or prophylaxis of associated with HIV infection neurological dysfunction is unknown.
The pharmacokinetics of zidovudine in patients over the age of 65 years have not been studied. However, given the age-related decline in renal function and possible changes in the peripheral blood, these patients need to be especially careful when assigning anadrol dosageand implement appropriate monitoring before and during treatment.
Patients with impaired renal function In severe renal impairment the recommended is 300-400 mg per day. Depending on the response from the peripheral blood and clinical effect may require a further dose adjustments. Hemodialysis and peritoneal dialysis have no significant effect on the elimination of zidovudine, but accelerate the elimination of the 5′-glucuronide of zidovudine. For patients with end-stage renal failure on hemodialysis or peritoneal dialysis, the recommended is 100 mg every 6-8 hours. patients with impaired liver function data obtained in patients with cirrhosis suggest that in patients with hepatic insufficiency may occur accumulation of zidovudine due to lower glucuronidation, and therefore may require a dosage adjustment. If monitoring zidovudine plasma concentrations is not possible, the doctor should pay special attention to clinical signs of intolerance to the drug and, if necessary, carry out adjustment of dose and / or increase the interval between doses of the drug.
Dose adjustment with adverse reactions on the part of the hematopoietic system adequate correction of dosing regimen – dose reduction or removal – may be required in patients with adverse reactions on the part of the hematopoietic system (in case of decrease in hemoglobin concentration to 75-90 g / l (4,65-5,59 mmol / l) or the anadrol dosage number of white blood cells to 0.75 1.0 x 10 9 / l). prevention of HIV transmission from mother to fetus has been shown to be effective prophylaxis following 2 schemes for pregnant women